Her professional acting career began when she featured in the 1923 movie Ateşten Gömlek (The Daughter of Smyrna) directed by Muhsin Ertuğrul.
Muhsin Ertuğrul was about to film a very popular novel written by Halide Edib Adıvar (1884-1964), which featured some dramatic events of the Turkish War of Independence (1919–1923).
The newly married wife Bedia Muvahhit (1897–1994) of Muhsin Ertuğrul's friend accepted to perform for the lead role.
[1][2][3] Neyyire Neyir starred in the same year also in the Muhsin Ertuğrul's next movie Kız Kulesinde Bir Facia (A Tragedy at Leander's Tower).
She acted on stage of Istanbul Municipal Theatre (Ottoman Turkish: Darülbedayi), of which director Muhsin Ertuğrul was appointed.
From 1941 on, Neyyire Neyir wrote in the journal Perde ve Sahne (literally: "Curtain and Stage"), she and her husband published together.