[1] Nguyễn presented his credentials to President Joe Biden on 19 April 2022.

[2] Prior to his term, he served at Deputy Foreign Minister from 2016 to 2022.

Nguyễn was appointed by President Nguyễn Xuân Phúc as Vietnamese Ambassador to the United States in 2022.

On September 10, 2023, Vietnam and the United States upgraded formal diplomatic ties to a Comprehensive Strategic Partnership.

[3] Nguyễn has criticized the US government's categorization of Vietnam's as a “non-market economy” since 2002.