Nguyễn Thị Duệ (阮氏叡, 1574 – 1654) courtesy name Ngọc Toàn (玉全), pen name Diệu Huyền (妙玄), Đào Hoa Am (桃花庵), was a Vietnamese Imperial consort and scholar, referred to as the first female doctor of Việt Nam.
The Mạc had lost all of Việt Nam except for the areas around Cao Bình county, which were under the formal protection of the Ming army.
During this time, Nguyễn Thị Duệ's family fled to Cao Bình to live with the Mạc lords.
However, her gender was discovered by emperor Mạc Đại Tông at the imperial party.
At the court of emperor Lê Thần Tông, she became the consort Chiêu-nghi (昭儀) by order of a new hereditary title Officer Nghi-ái (儀愛官).