From 1995 to 2002, he finished his most well-known work Kính vạn hoa (Kaleidoscope), a series including 45 volumes about 3 teenagers, their friendship and school life.

In May 2007, after five years hiatus, Nguyen Nhat Anh resumed Kính vạn hoa in the newspaper Thanh Niên in May 2007, containing nine fresh volumes.

In 2007, he published Cho tôi xin một vé đi tuổi thơ (Give Me a Ticket Back to Childhood) which became the best-selling in the 5th HCMC book fair with over 15,000 copies sold out within 10 days.

In 2010, he published Tôi thấy hoa vàng trên cỏ xanh (Yellow Flowers on the Green Grass) which was a huge success in Vietnam, selling 130,000 copies in total.

His latest work is Ra bờ suối ngắm hoa kèn hồng (Go to the stream to see the pink lilies), published in January 2022.