It was formed in the spring of 1937 at a meeting in Mike Cutt's Clay Pipe Inn in Tonawanda, New York.
In the early years of the NFL, schedules were balanced by granting associate memberships for either football or basketball to Batavia, Dunkirk, Jamestown, and Olean.
In 1959, Kenmore East entered competition and in 1961, the late Harry Blakeslee brought Lewiston-Porter into the fold from the Niagara Orleans League.
The Engineers, with more than 50 years of competition in the NFL had been a source of pride for the school, the city of Niagara Falls, the league and their alumni.
The Charter School for Applied Technologies left the Niagara Frontier League at the conclusion of the 2006–07 season.