In his senior season, he averaged 17.4 points,7.8 rebounds and 2.9 blocks per game and became the fourth player in school history to record 1,000 career points.

[8] On June 24, the Nets announced that Claxton had undergone successful arthroscopic labrum repair surgery on his left shoulder and was expected to miss the remainder of the 2019–20 season.

[citation needed] On May 12, 2021, Claxton scored a season-high 18 points, alongside five rebounds and two blocks, in a 128–116 win over the San Antonio Spurs.

On February 2, 2022, Claxton scored a season-high 23 points, alongside eleven rebounds and five blocks, in a 112–101 loss to the Sacramento Kings.

[20][21] In 2014, Claxton played for the United States Virgin Islands at the Centrobasket Under-15 Championship in Panama City, averaging a double-double of 10.6 points and 11.8 rebounds per game.

[22] He made another appearance for the Virgin Islands at the 2015 Centrobasket Under-17 Championship in San Juan, Puerto Rico, where he averaged 11 points and eight rebounds per game.

[24][25] In the summer of 2018, Claxton joined the senior Virgin Islands national team at qualifying competition for the 2019 FIBA World Cup.