The comics are usually three or four panels long, and are generally characterized by the juxtaposition of whimsical childlike imagery or fantasy with morbid, sudden or unexpected surreal humor.

[7] On February 18, 2008, Gurewitch announced he was cutting back on the production of the comic strip, saying "I feel I owe it to myself and the Perry Bible Fellowship not to turn a joyful diversion into a long career.

While some comics feature simplistic human figures with little more than a mouth and eyes for a face, other strips are extensively colored and meticulously detailed.

[citation needed] A recurring feature of the strip is simplistically-drawn human figures exhibiting little detail or realism, and heads reminiscent of smiley faces.

Some strips emulate the styles of famous illustrators such as Shel Silverstein, Edward Gorey, and Robert Crumb, made evident by marginal notes such as "(Apologies, R.

Rall called it a "twisted blending of the cute and profane", saying that "a lot of [its] humor involves violence, but the horror is tempered with a gentle, sweet tone.

"[17] Webcomics reviewer Eric Burns said in 2008 that "Perry Bible Fellowship is a comic that works in subversion humor... and Gurewitch is a master at it...

"[18] The Verge described PBF in a 2020 article as "one of the internet’s most beloved webcomics", saying that it "seamlessly match[es] hand-drawn artistry with subtle but devastating punchlines that reveal a heartbreaking truth about the world.