Bosa was named NFL Defensive Rookie of the Year and helped his team reach Super Bowl LIV.

Bosa attended St. Thomas Aquinas in Fort Lauderdale, Florida,[1] where he was a four-year starter and a multi-year first-team all-state player.

[3][4] Bosa played in all 13 games as a true freshman at Ohio State in 2016, recording 29 tackles, seven of which were for a loss, and five sacks.

On September 1, 2018, against Oregon State, Bosa had two sacks and a one-yard fumble recovery for a touchdown in the 77–31 win.

[9][10] Coming out of Ohio State, Bosa was projected to be the first overall pick in the draft by a majority of analysts and scouts.

A week before the draft, Bosa was criticized by some due to his political beliefs and controversial tweets, such as calling Colin Kaepernick a "clown", expressing support for U.S. president Donald Trump, and "liking" a post on Instagram that included racial and homophobic slurs as hashtags.

[19][20] In the next game against the Carolina Panthers, Bosa sacked Kyle Allen thrice and recorded his first career interception in the 51–13 win.

[25] In the Divisional Round of the playoffs against the Minnesota Vikings, Bosa sacked Kirk Cousins twice during the 27–10 win.

[28][29] In Super Bowl LIV against the Kansas City Chiefs, he recorded a strip sack on Patrick Mahomes during the 31–20 loss.

[52] He finished the 2023 season with 10.5 sacks, 53 total tackles (34 solo), four passes deflected, and two forced fumbles in 17 appearances and starts.

[54] In Super Bowl LVIII against the Chiefs, Bosa recorded six tackles and three quarterback hits in the 25–22 overtime loss.

[57] His brother, Joey Bosa, also played college football at Ohio State before being selected third overall by the San Diego Chargers in the 2016 NFL draft.

[58] Their father, John Bosa, was a first round pick by the Miami Dolphins in the 1987 NFL draft out of Boston College.

[60] During the 2024 season, after a 30–24 win over the Dallas Cowboys on Sunday Night Football, Bosa was seen wearing a white Make America Great Again hat with yellow text in support of Donald Trump at a postgame interview.

The NFL fined Bosa $11,255 after the game for wearing gear with non-sponsored branding, in accordance with the league rules.