[2] Bosa committed to play college football at Ohio State University in April 2012.

[8] On July 30, 2015, it was announced that Bosa would be suspended from the first game of the 2015 season with three other Ohio State football players for undisclosed reasons.

During the 2016 Fiesta Bowl against Notre Dame on January 1, 2016, Bosa was ejected in the first quarter for a targeting penalty when he made a hit on quarterback DeShone Kizer.

[12] Bosa was a highly decorated Buckeye receiving National and Conference honors beginning his freshman year.

Bosa met and interviewed with 13 NFL teams at the combine, including the Baltimore Ravens, New Orleans Saints, Dallas Cowboys, Cleveland Browns, and Tennessee Titans.

[24] On October 9, Bosa made his regular season debut against AFC West rival Oakland Raiders.

[27] Despite being limited to 12 games, Bosa finished his rookie year with 41 tackles, 10.5 sacks, and a forced fumble.

[32] He and Melvin Ingram formed one of the best pass rushing duos in the league, with Bosa totaling 70 tackles and 12.5 sacks - seventh in the NFL.

[45] He was named the AFC Defensive Player of the Week for his performance while his brother, Nick Bosa, won the award for the NFC.

[46] In Week 14 against the Jacksonville Jaguars, Bosa sacked rookie quarterback Gardner Minshew twice in the 45–10 blowout win.

[47] Bosa made the Pro Bowl after accumulating 11.5 sacks and 67 tackles in total for the 2019 season.

[50] On July 28, 2020, Bosa signed a five-year, $135 million contract extension with the Chargers, making him the highest-paid defensive player in the league.

[55] Bosa earned his fourth trip to the Pro Bowl but did not play after pulling out of the game with an undisclosed injury.

[56] Hall of Fame linebacker Junior Seau and Bosa are the only Chargers defensive players selected to four Pro Bowls over the first five seasons of a career.

[62] Against the same team in the Wild Card Round, Bosa committed a costly penalty by removing his helmet on the field in frustration after a late Jaguars touchdown.

[63] Trailing by four points, Jacksonville subsequently scored on a two-point conversion and later won the game with a field goal as time expired.

[68] His brother, Nick Bosa, also played defensive end at Ohio State, and was selected by the San Francisco 49ers with the second overall pick in 2019.