[2][3][4][5] His campaign, labelled "Nick's Crusade," resulted in a special program for 30 ventilator-dependent Alabamians (including himself and his younger brother) to continue home care after they turn 21 years old.

[4][5] Dupree was born in Morgantown, West Virginia, on February 23, 1982, with an unknown mitochondrial disease[5][6] believed to be related to the metabolic cycle and carnitine.

On September 13, 1991, an infected surgical site during a Luque rods surgery triggered a collapse that killed Dupree's remaining muscle tone.

From 2008 onward, Dupree lived in New York City with his partner Alejandra Ospina, who is also a disability rights activist.

[8] Dupree organized "Nick's Crusade", a campaign which attempted to gain continued in-home services for Alabamians with disabilities who are over the age of 21.