List of San Diego Padres first-round draft picks

The draft order is determined based on the previous season's standings, with the team possessing the worst record receiving the first pick.

[1] In addition, teams which lost free agents in the previous off-season may be awarded compensatory or supplementary picks.

[4] Dave Winfield (1973) is the only first-round pick of the Padres in the Baseball Hall of Fame, inducted in 2001 as an outfielder.

[5] Drafted as a pitcher, Winfield was named to 12 All-Star teams, won 7 Gold Gloves and 6 Silver Sluggers, and finished as high as third in MVP award voting (in 1979) over the course of his 22-season career.

[10] (Palo Alto, California) (Southlake, Texas) (Kent, Ohio) (Columbus County, North Carolina) (Loretto, Tennessee) (Roswell, Georgia) (Thompson's Station, Tennessee) (Severna Park, Maryland) (Buford, Georgia) (Flossmoor, Illinois) (Elk City, Oklahoma)

A man in a white pinstriped baseball uniform with purple sleeves and cap stands with his left leg lifted as if about to pitch a baseball.
Andy Benes (1988) was one of the Padres' five first-overall selections in draft history.
A dark skinned man in white pinstriped pants, a blue baseball jersey, and a blue baseball cap. The jersey and cap each have a red "C" on them.
Derrek Lee (1993) is one of nine players drafted from the Padres' home state of California.
A man in a white baseball uniform with "PADRES" on the chest stands with a baseball bat in his left hand as if having just taken a swing.
Khalil Greene (2002) finished second in Rookie of the Year voting in 2004.
A man in white pants, a blue baseball jersey with "PADRES" in gold on the chest, a blue baseball cap, and a tan baseball glove on his right hand prepares to pitch a baseball with his left hand.
Cesar Ramos (2005) was drafted with a supplemental pick the Padres received for losing David Wells via free agency.