Westbrook-Ihkine was named first-team all-state, all-district, and All-Central Florida as a senior after recording 84 receptions for 1,853 yards and 21 touchdowns.

Westbrook-Ikhine tore his anterior cruciate ligament during the first play of his junior year and used a medical redshirt.

[9] He was waived at the end of training camp during final roster cuts on September 5, 2020, but was signed by to the practice squad the next day.

[10][11] Westbrook-Ikhine was elevated to the active roster on September 14 for the team's Week 1 matchup against the Denver Broncos and was reverted back to the practice squad the next day.

[13] During a Week 5 42–16 victory over the Buffalo Bills, Westbrook-Ihkine recorded his first NFL reception on a seven-yard pass from Ryan Tannehill.

[15] Westbrook-Ikhine finished his rookie season with three receptions for 33 yards and a two-point conversion in 14 games and one start.

[18] During a Week 3 25–16 victory over the Indianapolis Colts, Westbrook-Ikhine caught four passes for 53 yards and his first NFL touchdown.

[23] During the regular-season finale against the Texans, Westbrook-Ihkine recorded four receptions for 78 yards and a touchdown as the Titans won on the road by a score of 28–25.

[31] During a Week 2 27–24 overtime victory over the Los Angeles Chargers, Westbrook-Ihkine caught three passes for 25 yards and his first touchdown of the season.

Starting on Week 6, he recorded touchdowns across four consecutive games, including one in a 20-17 overtime win against the New England Patriots.

He made the decision to include Ikhine, his biological father's last name, on his jersey upon joining the NFL.