In June 2010, Viacom gave the rights for Mexico to release their own Kids Choice Awards.

On 20 July 2010, another original series called Sueña conmigo premiered on the channel.

Through August 2010, Nickelodeon started to rerun the animated series Avatar: The Last Airbender to promote the 2010 film adaptation; with this, a new on-air logo was shown when the series was broadcast, an arrow blurring takes on/off in the Nick logo.

In late January 2012, MTV Networks Latin America announced another locally produced soap opera, Miss XV, that was premiered on 16 April 2012.

[12] Trailers are now textless and end credits on Panregional feed are replaced with short credits, indicating the show's name, production company and year, similar to the Nickelodeon channels in EMEAA.

[14] On November 14, 2023, the Mexico feed migrated to the EMEAA playout, screenbug & banners.

In 2010, Nickelodeon began to produce localized versions of the Kids' Choice Awards for its Latin American markets; after a one-off event in 2003, the Nickelodeon Mexico Kids' Choice Awards were relaunched on 4 September 2010 at Six Flags Mexico in Mexico City, hosted by Omar Chaparro and Anahí.

Revista Nick (Nick Magazine) was launched on 27 November 2004 in Mexico, ending in April 2010, five months after the American version was ended due to the continued migration of network content to the Internet.

It started airing on 4 February 2013 on television providers Cablevisión, Megacable and Cablecom.

[21][22] The channel was replaced by the US feed of NickMusic in many cable providers by the end of 2020 and later was shut down as of December 2020.

NickMusic started simulcasting their US feed on 1 September 2020, replacing VH1 MegaHits and Nicktoons in select Latin American countries.