Nicole Nieves was in New York City borough of the Bronx, on October 6, 1989, having no left hand since birth.

[1] Nieves competed at the World Para Volleyball Championship for the first time in June 2014, at which she and Kaleo Kanahele Maclay each scored 7 points in a match against China.

[4][5] Nieves also represented the United States at the Parapan American Games, first in the 2015 edition and won a gold medal.

[7] Nieves represented the United States at the 2016 Summer Paralympics in sitting volleyball and won a gold medal.

[10] Along with wheelchair basketball player Steve Serio, she served as one of two flag bearers for Team USA at the 2024 Summer Paralympics opening ceremony.