"My Friend" has been played by DJs and record producers such as Tiësto, Axwell, Fedde Le Grand, Sander van Doorn and many more.

[7] In 2012, Romero achieved popularity with the recording "Toulouse", which became a mainstay on the Beatport Top Ten for a significant period of time.

[8] His popularity has risen in recent years, and he has attained a joint residency with David Guetta at party hot spot Ibiza for the summer of 2012.

[24] Beside his music, he is up for different kinds of charity projects, as '10.000 Hours – People Planet Party' which is made to help renovate playgrounds for disadvantaged kids.

"Legacy" was used as the backing track by Australian television network Channel Seven in on-air promotions for the 2014 season return of hit show Revenge.

[citation needed] In August 2014, Nicky partnered with EDM lifestyle brand Electric Family to produce a collaboration bracelet for which 100% of the proceeds are donated to Fuck Cancer.

In November 2015, Romero indicated that he had been suffering from anxiety which forced him to reduce his touring commitments and scale back his studio work.

[26] In addition to all "Nicky Romero" singles, he also co-produced the track "Right Now" (featuring David Guetta) from Rihanna's seventh studio album Unapologetic,[27] which was released on 19 November 2012.

Romero also co-produced "Bang My Head" (featuring Sia) and "No Money No Love" from David Guetta's 2014 album titled Listen.

[30] They have released music by notable underground electronic artists such as Blasterjaxx, Don Diablo, R3hab, Vicetone, Stadiumx, Thomas Gold, Arno Cost and Volt & State.

[37] In 2021 Nicky Romero expanded his output by delivering an in-depth music production masterclass for aspiring DJs and producers.