Nicolaas Ruysch (c. 1496 – 12 October 1558) was a canon, vice-dean and treasurer of St. Salvator's Church in Utrecht and councilor of the Bishop of Liège, Robert of Berghes.

He studied in Leuven and Orléans and is said to have obtained a doctorate in law in Italy.

[1] Ruysch, together with Bishop of Utrecht George van Egmond and his then vicar Nicolaas van Nieuwland, was involved in the arrangement that the regulars of Stein - after the fire in 1549 that destroyed their monastery - could move into the monastery in 1551.

It concerns the representation of Jesus shown to the people by Pilate, ecce homo.

Ruysch was also involved, together with Herman Lethmaet, in raising funds for the manufacture of the new stained glass in the St. John's Church in Gouda.