Born in Fălticeni, his family were boyars of small and medium importance; his parents were postelnic Matei Gane and his wife Ruxandra (née Văsescu).
Gane intended to study fine arts in Paris, but encountering opposition from his family, opted instead for a government career.
[3] His appeals court colleague Vasile Pogor and the brothers Iacob and Leon C. Negruzzi introduced Gane to the recently founded Junimea society, of which he remained a leading member, even though in 1883 he joined its political rival, the National Liberal Party (PNL).
[5] During Gane's time as mayor, his city acquired paved roads and gas lighting, as well as a new building for the Iași National Theatre in 1896.
[6] Three Gane-related sites in Iași are listed as historic monuments by Romania's Ministry of Culture and Religious Affairs: his early 19th-century house, now a museum; his 1943 bust, located in Copou Park; and his grave in Eternitatea cemetery.