He moved to the United States to attend the Wharton School at the University of Pennsylvania where he received a bachelor degree in Economics.

Between 1990 and 2005, he held a variety of roles in New York and Buenos Aires including Head of the Investment Banking Division in Latin America.

[6] On 9 February 2021 HKEX announced that it had appointed Aguzin as chief executive officer, effective 24 May 2021 for a term of three years, until 23 May 2024.

[1][2] The appointment of a non-Chinese person as CEO of HKEX was reportedly unexpected by market observers, who noted Aguzin will have to balance the demands of authorities in Beijing with those of Hong Kong's trading community.

His term was marked by difficulties which included regulatory crackdowns, COVID-19 pandemic and a decline in profits leading to the HKEX share price plunging 42%.