Nicolas Perrenot de Granvelle (1486–1550) was a Burgundian politician who served as a close trusted adviser to Emperor Charles V. He was made suzerain of the imperial city of Besançon and held an influential position in the Netherlands.
Nicolas Perrenot de Granvelle quickly became a closely trusted advisor and was appointed chancellor of the empire.
His sons and sons-in-law (Granvelle family) went on to occupy prominent positions at the imperial court.
The eldest surviving son, Antoine Perrenot de Granvelle, become Archbishop of Mechelen and a cardinal as well as serving as a diplomat and adviser to Charles V. Another son, Jérôme de Perrenot, became a diplomat in the service of Ferdinand I, Holy Roman Emperor and guardian of the young William the Silent.
The youngest son, Frédéric Perrenot de Champagney, served the Habsburgs as a soldier and diplomat.