The earliest solid record of his life is February 7, 1420, when he was employed at Florence Cathedral as a singer; on the evidence of his motet Letetur plebs, which includes the comment in the score "composed in Taranto, in a great hurry" it is presumed he was already active as a composer prior to coming to Florence in 1420.
Just a few months later – June 1 – Pope Martin V hired him during a trip to Florence, taking him back to the papal choir in Rome, probably in September when he returned there, having successfully ended the Western Schism a few years before.
Zacharie remained in the choir until 1424, and after an absence of ten years joined again for a few months in 1434; his whereabouts between those two periods is unknown.
At the end of his life he was a chaplain at the church of Santa Maria in Ceglie Messapico, about 40 km west of Brindisi in the far southeast of Italy.
Only three works by Zacharie have survived with reliable attribution: a motet, a Gloria, and a secular song, a ballata.