Nicolaus van Esch (Eschius) (1507 in Oisterwijk near 's-Hertogenbosch, the Netherlands – 19 July 1578) was a Dutch Roman Catholic theologian and mystical writer.
In 1530 he was ordained priest, and then settled in Cologne in order to devote himself to higher studies and the practice of Christian perfection.
In Cologne, too, he made close friendships with several members of the Carthusian Order, among them Johann Landsberger, Gerhard Homontanus, and Theoderich and Bruno Loher.
Though his health did not allow him to become a member of the order, he lived in the monastery, for a time at least, and followed its rule of life as closely as possible.
In 1538 Nicolaus was appointed pastor of the Béguinage at Diest; after a year he surrendered his charge for a time, but took it up again, with such success that after his death he was commonly spoken of as the saintly Father Eschius.