With her former partner Matteo Guarise, she is a seven-time Italian national champion (2016–22) and has represented Italy at the 2014, 2018 and 2022 Winter Olympics.

With her previous partner Yannick Kocon, she was a two-time Italian national champion (2009, 2010) and competed at the 2010 Winter Olympics.

Della Monica competed as a single skater through the 2006–07 season and is the 2005 Italian national bronze medalist.

Della Monica started skating pairs in 2007 when she teamed up with Yannick Kocon, who was also a single skater until then.

Their partnership ended in January 2011 — Della Monica had a chronic inflammation in her left knee and her recovery time was uncertain.

[3] Della Monica teamed up with former World champion roller skater Matteo Guarise in late November 2011.

Della Monica/Guarise were named along with Italian champions Stefania Berton / Ondrej Hotarek as Italy's pairs entries at the 2014 Winter Olympics in Sochi.

[9] In the 2014–15 season, Della Monica/Guarise competed at two Grand Prix events, placing fifth at the 2014 Cup of China and sixth at the 2014 Trophée Éric Bompard.

"[11] They won a second silver medal at the 2018 Rostelecom Cup, becoming the first Italian pair team to qualify for the Grand Prix Final, a goal they had set for themselves at the beginning of the year.

They placed third in the short program, 0.12 points ahead of Aleksandra Boikova / Dmitrii Kozlovskii of Russia, and were awarded a small bronze medal for the result.

They returned to competition at the 2019 Icelab International in Italy, taking the silver medal, a week before their first Grand Prix.

[24] Della Monica/Guarise were scheduled to compete on the Grand Prix at the 2020 Internationaux de France, but the event was cancelled due to the pandemic.

[30] They were initially assigned to the 2021 Cup of China as their first Grand Prix of the season, but following the event's cancellation they were reassigned to a special home 2021 Gran Premio d'Italia, hosted in Turin.

Della Monica said afterward that she intended to retire at the end of the season to start a family, while Guarise expressed a desire to continue, joking "maybe she can be my coach one day.

[36] In the pairs event, they placed tenth in the short program after Della Monica fell on her jump attempt.