Ghilardi/Ambrosini competed at several Challenger events at the beginning of the season, including taking the silver medal at the 2018 CS Inge Solar Memorial.

[7] With the pandemic continuing to affect events, Ghilardi/Ambrossini started their season off at the 2020 CS Nebelhorn Trophy, which was only attended by pairs teams training in Europe.

[8] They were third after the short program, and after the withdrawal of Hase/Seegert, the leaders after that segment, they narrowly won their first Challenger Series title over silver medalists Hocke/Kunkel.

[12] They had initially been assigned to compete on the Grand Prix at the 2021 Cup of China, but following the event's cancellation, they were reassigned to a special home 2021 Gran Premio d'Italia, held in Turin.

Ghilardi said it was an emotional moment for them to have made the final group of the free skate alongside the elite Russian teams.

[18] Competing at the 2022 Winter Olympics in the pairs event, Ghilardi/Ambrosini placed sixteenth in the short program after Ghilardi fell twice, one of those being on her triple Salchow attempt.

[20] The team was scheduled to finish the season at the 2022 World Championships, but withdrew after Ghilardi tested positive for COVID.

[23] They won the free skate as well, setting a new personal best in total score (189.74), and taking the gold medal over Germans Efimova/Blommaert by almost twenty points.

With Russian pairs banned from competing due to the Russo-Ukrainian War, the podium at the European Championships was considered far more open than in recent seasons.

[16] They won a silver medal in their second Challenger appearance of the season, the 2023 CS Finlandia Trophy, before winning the Diamond Spin.

"[31] At the 2023 NHK Trophy, they placed fourth in the short program after both made jump errors, but rose in the free skate to win the bronze medal.

[34] After winning their first Italian title, Ghilardi/Ambrosini competed at the 2024 European Championships, coming fifth in the short program after losing levels on their step sequence and death spiral elements.

"[35] During the off-season, Ghilardi and Ambrosini worked with their choreographers to create a new short program to the song "El Tango de Roxanne" from Moulin Rouge!, with the intention of depicting the worldwide social issue of violence against women.

[36] Beginning the season by competing on the 2024–25 ISU Challenger Series, Ghilardi and Ambrosini finished sixth at the 2024 John Nicks International Pairs Competition and fourth at the 2024 Lombardia Trophy.

[16] Having initially skated to music from The Phantom of the Opera, the pair decided to return to their Dracula-themed program from the previous season following these events.