[3][4] Nason's career in government began when she worked for U.S. Representative Porter Goss, Chairman Henry Hyde, and as Assistant Commissioner for Congressional Affairs for the United States Custom Service.

[1] Nason began working at the United States Department of Transportation in March 2003 when she was appointed as Assistant Secretary for Governmental Affairs.

During her time at NHTSA, Nason managed an international tire recall,[7] as well as a problematic Consumer Reports car-seat safety investigation.

[19] Also in 2020, during the COVID-19 pandemic and the closure of eateries, Nason opted not to fine or punish states that allowed food trucks to operate in rest areas of federally funded Interstate roads.

[22] In April 2022, Nason joined The Boeing Company as the Vice President of Federal Affairs for Aerospace Safety, Commercial Aviation, Sustainability, and Corporate Policy.