Together Nicole Natalino, Pablo Holman, Tomás Manzi, and Barbara Sepúlveda achieved a successful musical career.

With great success in South and Central America their album, Vuelo, was edited in more than six countries and the group passed to form a part of EMI Records.

Due to their busy schedule they had to decline the invitation to Viña del Mar International Song Festivalthat same year they released the first single of their new album Sobrevive.

At that moment, the three remaining members of Kudai and their manager Pablo Vega decided to replace her with Ecuadorian Gabriela Villalba, ex-member of Kiruba who had been the opening act to the group during a few presentations in Ecuador.

On October 19, 2006, Kudai won the MTV Video Music Award Latin America for "Best Pop Artist" with their first album "Vuelo".

[citation needed] Nicole work together with the vocalist of Lucybell Claudio Valenzuela on the debut album and ex-producer of Kudai Gustavo Pinochet and his new band SUM.

The expectation of the fans from outside was enormous and the single "No Hay Más" then went on the radio in Argentina, Bolivia, Peru, Mexico, Ecuador, Venezuela and Colombia.

Later release her second music video "I will" also announcing its first solo concert for the January 18, 2009 filled that day passed all the subjects of her album and signed autographs after the show to their fans.

On August 16 she participated in the concerts in Chile at the Teatro Caupolicán meeting for the first time to 13 local female performers that stand between Nicole, Denisse Malebrán, Javiera Parra, Francisca Valenzuela among others, being the youngest of the group which represented the younger generation as well as a touch pop.

Besides music Nico joined the campaign to prevent teen pregnancy by saying "the decision has to be initiated sexually mature and after a deep personal process".

The cut out for the obvious commercial emphasis behind the production at the expense of a quality work successfully performed more faithful to the original topic.

But do not stay within the 5 most voted songs Camino a Viña program delivered on November 28 on Channel 13 in conjunction with National Television of Chile Twitter Nico confessed her confusion by the negative results but the next day at the same half said "Sometimes you win sometimes you lose but family and friends will always be there!

In January 2010 she participated in a tour called Tour Glass Show and traveled throughout the southern and central Chile in the Truck Glass: The route of the Chilean music with the band electro-pop of The Plugin, band led by former La Ley, Rodrigo "Coti" Aboitiz, Nabu and the revelation of the electro-rock, 2009 Mawashi.

In the concerts that Kudai performed in Chile, Peru, Bolivia and Mexico during 2017, Natalino also sang "Seré", from her solo career (Holman accompanying her in the chorus).