She served as the Secretary of State for Asylum and Migration in the government of Alexander De Croo between 28 June 2022 and 3 February 2025.

From August 2008 to May 2009, she was a legal advisor at the Flemish Minorities Center and from May 2009 to November 2013, she was a researcher at Ghent University.

[1] In November 2014, De Moor was a migration specialist in the cabinets of CD&V ministers Kris Peeters, Nathalie Muylle and Koen Geens, and in October 2020, she became head of cabinet to State Secretary for Asylum and Migration Sammy Mahdi.

In the 2019, Flemish elections, she was the first successor on the CD&V list in the Brussels-Capital constituency,[2] obtaining 379 votes.

At the end of June 2022, the party nominated De Moor as Secretary of State for Asylum and Migration, in charge of the National Lottery and Deputy to the Minister of the Interior, Institutional Reforms and Democratic Renewal, in the De Croo Government, to succeed Mahdi, who had become party chairman.