Ladommatos studied for his first degree in Mechanical Engineering at Queen Mary College (University of London).
[3] Following his studies, Ladommatos worked as a Project Engineer with multinational professional services firm Arup.
He then went on to become Dean of the Faculty of Technology & Information Systems between 1998 and 2001 and then Pro-Vice Chancellor, Research & Enterprise between 2001 and 2003, all at Brunel University.
In 2004, Ladommatos began working at UCL where he held the position of Kennedy Chair and was the Head of the Department of Mechanical Engineering until September 2013.
Ladommatos co-authored the book Engine Instrumentation, Flow and Combustion Diagnostics with Professor H. Zhao, published in 2001 by SAE.