The NiD 640 was designed with a highly-efficient elliptical wing, a readily swappable engine arrangement, and made copious use of metal throughout its construction.

[1] It was marketed towards a variety of roles in addition to its primary use as a passenger transport; it could be readily used as a trainer aircraft, carrying up to four trainees that could be rotated through the cockpit throughout a single flight.

[1] This cockpit accommodated a two-person crew and was furnished with dual flying controls, which could be switched on and off at the pilot's discretion; this function was desirable for the aircraft's potential use as a trainer.

[4] Directly behind the cockpit and underneath the wing was the passenger cabin, which could comfortably accommodate up to four travellers, one of the seats for which would typically removed during boarding to better facilitate entry and egress.

[7] The horizontal surface was elliptical and could be adjusted on the ground; it shared a similar structure to that of the wing, comprising spruce, poplar, and plywood elements.

One aircraft was powered by a 175 kW (235 hp) Armstrong Siddeley Lynx Major engine and designated the NiD 642 but it did not find a buyer and was ultimately scrapped.

Seven NiD 641s were flown by Société des Transports Aériens Rapides (STAR), a subsidiary of Nieport-Delage, on cargo and passenger services from Paris.