On leaving University college he also spent eighteen months working as a free-lance journalist, writing features on social issues for medical journals and editing an employment magazine.
In January 1966 he and two partners, Sheila Cohen and John Pearse, opened the original rock-chic fashion boutique, Granny Takes a Trip.
While still involved in Granny Takes a Trip, in 1967 he teamed up with fellow artist Michael English and together they began designing many of the quintessential British pop posters of that era.
An exhibition entitled Haphash Takes a Trip: The Sixties Work of Nigel Waymouth was due to open at the Idea Generation Gallery in London in September 2011.
His works have been commissioned and collected by Mr. and Mrs. Rupert Murdoch, The Duchess of York, The Duke of Devonshire, Mr. and Mrs. Tom Hanks, Mr. Dominick Dunne, Dame Diana Rigg, Mr. Peter Morton, Mr. & Mrs. Eric Idle, Dr. & Mrs. Mortimer Sackler.