Nigeria competed at the 2022 World Athletics Championships in Eugene, United States, from 15 to 24 July 2022.

[1] On 24 July 2022, Nigeria achieved its first world gold medal at the World Athletics Championships after Tobi Amusan won the women's 100 metres hurdles final.

[2] Amusan set a new world record when she ran a 12.12 time in her semi-final heat before she bettered that in the final when she crossed the line in a time of 12.06, however, her time in the final was not considered as the new world record due to the wind reading (+2.5 MPS) was over the allowable.

[1][6] Sprinters Usheoritse Itsekiri, Seye Ogunlewe and hurdler Tobi Amusan were included in the teams for the men and women's 4 × 100 metres relay respectively, but finally they had no participation.

In the same way, Sikiru Adeyemi and Knowledge Omovoh were part of the mixed 4 × 400 metres relay team, but had no participation.