[2] Her father, Arif Hussain,[5] moved to the UK at the end of 1984,[6] was the Imam for Chesham Mosque, and was made a Member of the order of the British Empire in the 2020 New Year Honours;[7] her uncles, cousins, and grandfathers were subsidy farmers.

[12] In 2020, during the COVID-19 pandemic in the United Kingdom, Arif began uploading content to her TikTok account to dispense information quickly,[11]: 14:48  having been inspired to do so by her patients.

[14] In August 2023, the Times noted that she "often subtitles or narrates her posts about female health in Punjabi and Urdu" and that the only words for menopause in these languages translated to "barren" and "off the rag".

[16] The book makes use of coloured backgrounds to aid neurodivergent people, a decision inspired by her own dyslexia, and includes content on trans health and LGBT issues and life-like diagrams of both brown and black bodies.

[2] Sarah Graham of the i suggested in August 2023 that the book contained the first published images of lichen sclerosus on non-white skin, complimented it for addressing patients as equals, and opined that The Knowledge "blends her no-nonsense, stigma-busting approach with her cultural awareness, her characteristic warmth, and her clinical expertise".

She also mentioned that she would give more women vibrators for medical reasons, on the grounds that orgasms help pelvic floor muscles, lower blood pressure, and release endorphins which help relieve pain and stimulate oxytocin.