The station was opened on 2 June 1973 and is located on the Tilburg–Nijmegen railway.

The train services are operated by Nederlandse Spoorwegen.

The following services currently call at Nijmegen Dukenburg: There is a bus station near the station, also called Nijmegen Dukenburg.

The name of this station used to be Brabantse Poort but was changed at the end of 2013 after an online poll.

More regional services operate from the Centraal Station.