[1][2] He became widely unpopular due to his harsh taxation and meddling with Constantinople's grain supply, as well as for his neglect of Asia Minor in the face of Turkish encroachment.
[1][2][3] He was released by the new emperor, Romanos IV Diogenes (r. 1068–1071), and appointed as praetor (civil governor) of the combined themes of Hellas (Central Greece) and the Peloponnese.
[1][2] On the assumption of power by Michael VII in 1071, Nikephoritzes was recalled to serve in the imperial government by the new emperor's uncle, the Caesar John Doukas, who valued his administrative skills.
Not only did he soon sideline the other ministers, including the hereto powerful Michael Psellos, but in autumn 1073, Nikephoritzes forced the Caesar himself to withdraw from active participation in the governance of the Byzantine Empire and retire to his estates.
Michael VII prevaricated in his reply, whereupon Nestor with his Pecheneg allies withdrew north into the Paristrion, which hence and for the next two decades effectively passed out of imperial control.
With the exception of Kekaumenos, who praises him as "an excellent man in everything, most reasonable, experienced in both military and administrative matters although a eunuch, generous, very clever, and capable of understanding and speaking properly", the other sources all relate stories of his greed and corruption.
Alexios Komnenos, who had risen to high command under Nikephoritzes, suggested the forcible suppression of the opposition, but Michael VII eventually decided to abdicate in favour of Botaneiates, on March 31, 1078.