[2] He finished his education at the Krastyo Sarafov National Academy for Theatre and Film Arts, in the class of Prof. Philip Philipov.
He is married to Bulgarian singer Marya Koseva; they have two sons.
Nikola Anastasov began performing in the theaters in Vratsa (1955–1956) and Varna (1956–1957).
His first important role was in the comedy Когато розите танцува (When The Rose Dances) by Valeri Petrov.
His later well known roles include Trimata ot zapasa (1971), Osmiyat (1969) and Samo ti, sartze (1987).