Nikolsky Uyezd (Russian: Никольский уезд) was one of the subdivisions of the Vologda Governorate of the Russian Empire.
It was situated in the southern part of the governorate.
In terms of present-day administrative borders, the territory of Nikolsky Uyezd is divided between the Nikolsky, Babushkinsky and Kichmengsko-Gorodetsky districts of Vologda Oblast and Podosinovsky District of Kirov Oblast.
At the time of the Russian Empire Census of 1897, Nikolsky Uyezd had a population of 172,187.
Of these, 99.9% spoke Russian as their native language.