[2] Nikon claims improved ultra-high image sensor sensitivity with up to ISO 102400,[3] HD movie capability for extremely low-lit situations,[4][5] image sensor cleaning, optimized workflow speed, improved autofocus and metering, enhanced built-in RAW processor, quiet shutter-release mode, up to 4,200 frames per battery charge and other changes compared with the D3.

Many independent reviews[6][7] and comparisons[8][9][10] show that image noise was improved up to 2 stops compared to the Nikon D3 or D700.

Other functions, especially autofocus and speed, support this, causing PhotographyBlog to conclude: "hand-held photography anytime, anywhere, without flash".

In April 2010, the D3S received a Technical Image Press Association (TIPA) 2010 Award in the category of "Best Digital SLR Professional".

[16] In August 2010, the European Imaging and Sound Association (EISA) presented the D3S with the European Professional Camera 2010-2011 award, citing high ISO sensitivity combined with low noise and a high level of detail.