Nikolaos "Nikos" Papanikolopoulos (Greek: Νικόλαος "Νίκος" Παπανικολόπουλος; born April 21, 1979) is a retired Greek professional basketball player and current basketball coach.

During his professional playing career, Papanikolopoulos played with the following clubs: Near East, AEK Athens, Aris, Ionikos NF, Olympiacos, Gymnastikos S. Larissas, AEL, Teramo, Kolossos, Peristeri, Iraklis, Ilysiakos, Panelefsiniakos, and Ikaros Chalkidas.

During his playing career, he won the Greek 2nd Division championship in 1998, and the Greek Cup title and the European-wide secondary level FIBA Saporta Cup championship in the 1999–2000 season.

Papanikolopoulos played with Greece's under-26 national team at the 2005 Mediterranean Games.

He also played with the senior men's Greek national basketball team.