Aguillo successfully ran for mayor of Cabuyao in 2004 as her husband was term-limited.
It is a 53.337-hectare (131.80-acre) resettlement site in Barangays Marinig, Niugan and Banay-Banay for families displaced by the PNR Northrail-Southrail Linkage project from the rail tracks in Cabuyao and Makati.
[2] Numerous development projects were accomplished during her three-year term as the first lady mayor of the town.
Her husband instead ran again for mayor but was defeated by incumbent vice mayor Isidro Hemedes Jr. After losing in 2010 mayoral election, Aguillo together with her vice-mayoral bet Benjamin C. del Rosario filed a petition to Commission on Elections, Isidro Hemedes Jr. and Rommel A. Gecolea declaring for an election protest.
[3] Prior to seeking relief with the High Court, Aguillo and del Rosario lost in an en banc decision of the Commission on Elections (Comelec) and in the Laguna Regional Trial Court on June 21, 2010.