It lies approximately 197 kilometres (122 mi), by road, southeast of Juba, the capital of South Sudan and largest city in the country.

[1] The town also lies approximately 120 kilometres (75 mi), by road, north of Gulu, Uganda, the nearest large city.

[4] On April 7, 2014, the Mountain Trade and Development Bank expanded into the Eastern Equatoria state by opening a new branch in the town of Nimule.

Uganda's energy minister Simon D'Ujanga said "400 kilo-volts of power will be supplied to the towns of Kaya and Nimule to boost socio-economic activities in the border areas.

During the calendar year ending December 2019, South Sudan imported goods worth US$364 million from Uganda.