The meeting house, the third one on the site, was built by a group of Friends ("Quakers") from the Cape Cod region, Nantucket and Rhode Island in 1780.

Attendance at meetings dwindled over the course of the 19th century, and in 1897 control of the property was turned over to the Nine Partners Burial Ground Association.

In 1989 it was listed on the National Register of Historic Places as part of a Multiple Property Submission of Quaker meeting houses in Dutchess County.

[3] The meeting house and cemetery are located on a 9-acre (3.6 ha) lot at the northeast corner of the road intersection.

[4] The interior is one large room, divided into two chambers width-wise with counterbalanced, sliding wooden partitions through the middle of both floors.

A feature unique to Nine Partners among meeting houses in the area is the vestibule created later by building a lengthwise interior wall along the south side.

[1] In the central area there is a wood stove placed on a stone hearth and an oil lamp mounted on a post.

With few exceptions, such as the placement of one lengthwise interior wall creating the above-mentioned vestibule, gutters added in the 1970s, composite shingles on the roof introduced the following decade, and basic repairs and maintenance, the structure remains unaltered from is original state.

As such they reflect Quaker aesthetics enough that that section of the cemetery is considered a contributing resource to the National Register listing.

[1] In 1767, the meeting began considering whether slavery was compatible with Christianity, one of the first instances of an American congregation taking up the question.

They both decided that they could not accept slaveholders or any who profited from slavery as members or financial supporters, and continued to work to convince local slaveowners to free those they held.

Through the Civil War, the Nine Partners Meeting and School was known to coordinate the Underground Railroad activities in Dutchess and Columbia counties.

[1] The large brick meeting house was built in 1780 at more than twice its originally budgeted cost, possibly due to the members' inexperience in bricklaying.

Situated to the east and slightly uphill was the former store of Samuel Mabbett, a somewhat strayed Friend[11] and known to be a Loyalist during the Revolutionary War.

In 1897, the brick meeting house and cemetery were turned over to the Nine Partners Burial Ground Association, ending Quaker ownership of the site.