After the death of her husband in 1804, Nino was a regent for her underage son, Levan until 1811, and helped bring Mingrelia and Abkhazia, a neighboring principality of her in-laws, under the hegemony of the Russian Empire.

Princess Nino was born in Tbilisi as the sixth child of then-Crown Prince George and his first wife, Ketevan Andronikashvili, in 1772, in the lifetime of her reigning grandfather, Heraclius II of Georgia.

These marriages were intended to cement an alliance of the Georgian potentates which had been concluded through the efforts of Heraclius II's minister Solomon Lionidze in June 1790.

Levan had been held since 1802 as a hostage by Kelesh Ahmed-Bey Shervashidze, Prince of Abkhazia, in return for his help to Grigol in the power struggle in Mingrelia.

In 1810, Nino sent 1,000 soldiers to the aid of her Abkhazian protégé, Sefer Ali-Bey Shervashidze, who deposed his pro-Ottoman brother, Prince Aslan-Bey, and brought Abkhazia under the Russian protectorate.

Early in 1820, when Nino was vacationing at Georgiyevsk, Giorgi fell under the suspicion of collaborating with the rebels in Imereti, whom his elder brother, Levan, fought in the Russian ranks.