Princess Ketevan was born into the Andronikashvili family, one of the leading noble houses of the eastern Georgian kingdom of Kakheti, claiming their descent from the Byzantine Komnenos dynasty.
Princess Ketevan married George, the eldest son of King Heraclius II and heir to the throne of the Kingdom of Kartli and Kakheti, in 1766.
[1][2] The marriage helped the Andronikashvili clan, especially Ketevan's brother Revaz, advance their cause at the royal court against the rival faction patronized by Heraclius II's consort Darejan Dadiani.
Years later, in 1795, Prince Revaz would prevent the Kiziqian troops from coming to aid to the beleaguered king Heraclius, desperately battling the Persians at his capital city of Tbilisi.
Encountered by a marauding band of some 500 Lesgian mountaineers on the road to Tbilisi, Ketevan personally led her entourage of 300 cavalrymen into fighting and won a victory.