[2][3] Nino Machaidze was born to a Georgian language teacher mother and an economist father and raised in Tbilisi.

At the age of six she began piano and vocal lessons at a school affiliated with the Tbilisi State Conservatoire, which she later also attended.

At the academy, she studied with Luciana Serra, Leyla Gencer, and Luigi Alva and also attended masterclasses of Renato Bruson and Mirella Freni.

[5] In 2006 she debuted at the theater as Najade in Ariadne auf Naxos[6] and won first prize in the Leyla Gencer Voice Competition in Istanbul.

[18] In 2009, she was cast as Elvira in I puritani opposite Juan Diego Flórez at the Teatro Comunale di Bologna,[19] before repeating Juliette at La Fenice.

[22] Machaidze was cast as Donna Fiorilla in a new production of Il turco in Italia at the Theater an der Wien in July 2009.

[43][44] The season also saw her return to Hamburg for the premiere of Andreas Homoki's new Luisa Miller, her debut in the title role, and La traviata.

[46] In 2015, she made several role debuts after singing Fiorilla in Turin:[47] Contessa di Folleville in Il viaggio a Reims (Dutch National Opera), Micaëla in Carmen (La Scala), Ninetta in La gazza ladra (Rossini Opera Festival), and Inès in L'Africaine (Deutsche Oper Berlin),[48][49] followed by Gilda in Toulouse.

[51] She returned to the Verona Arena for Violetta,[52] before heading to the Royal Opera House Muscat for Roméo et Juliette with the Opéra de Monte-Carlo.

[53] She then made Teatro di San Carlo and the Grand Théâtre de Genève debuts respectively with Desdemona and Mimì.

Despite announcing withdrawal from La traviata in Paris claiming medical treatment, she stepped into Otello at the Oper Frankfurt, in the Michieletto production she premiered.