[1] The store sells a wide variety of Nintendo video games and merchandise, including apparel, hardware, and accessories that are exclusive to the store, such as Japanese Mario character plushies, and special guides to a wide variety of Nintendo games.

Nintendo New York regularly holds tournaments and shows for new games, giving early releases and prizes to winners.

[1] On September 25, 2005, developer Shigeru Miyamoto visited the Nintendo World store to commemorate the release of Nintendogs and the 20th anniversary of Super Mario Bros.[4] On July 10, 2010, Dragon Quest creator Yuji Horii visited the Nintendo World store to commemorate the release of Dragon Quest IX: Sentinels of the Starry Skies.

[6] On November 17, 2012, the Nintendo World store had a big launch event for the Wii U, with hundreds of people in attendance.

Two days later, on March 16, 2020, they announced on Twitter that they would be officially on full closure due to the COVID-19 pandemic in New York City.

[17] The museum on the second story once displayed a Game Boy previously owned by Dr. Stephan Scoggins, a medic who was deployed during the Gulf War.

While the technicians that received the console determined it was a "lost cause", they discovered it could still be powered on and that the Start and Select buttons still worked, inserting a copy of Tetris to test it with.

[18] The damaged Game Boy was later displayed at the store since its opening as a testament to the console's durability, remaining powered on and receiving timely maintenance until it was confirmed in 2023 that it was returned to Nintendo of America's headquarters in Redmond, Washington.

[28][29] Additionally, Nintendo launched official pop-up stores in 2021 at various Japanese cities,[30] and later in 2023 in Seoul,[31][32] Singapore,[33] and Hong Kong.