The sori are round and large, occurring in single rows between veins at the far end of the leaf.

[1] It can be difficult to distinguish from N. albopunctatissimum, but that species has narrower leaves and is mostly found growing on rocks or on the ground, as well as occupying a different range.

[6] According to Thomas Croat, it is probably the most common fern found on Barro Colorado Island, Panama.

[3] Niphidium crassifolium is known to grow on Socratea exorrhiza, occurring on 12% of individuals on Barro Colorado Island.

[5] In Northern Peru the fresh stem is used in traditional medicine to treat inflammation of internal organs.