During the final game of the 1923 season with intrastate rival Miami University, UC player James Gamble "Jimmy" Nippert sustained a spike wound injury.

He died a month later of blood poisoning, reportedly due to having been infected by droppings left after a pre-game chicken race.

The first game played on the site originally called Varsity Field in Burnet Woods was on November 2, 1901, vs the Ohio University Bobcats.

[11] In 1915, construction was completed on the first sections of a brick and concrete structure to replace the wooden stands and continued for several seasons as funds were raised.

The field is slightly offset from a conventional north–south alignment, configured north-northeast to south-southwest at an approximate elevation of 800 feet (245 m) above sea level.

Former UC head coach Brian Kelly called for an expansion of Nippert, the smallest stadium in the Big East Conference.

On December 18, 2012, President Santa J. Ono and then Athletic Director Whit Babcock unveiled the long-anticipated plans to update and expand Nippert Stadium.

The western concourse also boasts improved general fan amenities, including concession stands, restrooms, and more efficient in-stadium traffic flow.

However, local United Soccer League club FC Cincinnati sold out Nippert Stadium in July 2016 after the renovations, and announced a crowd of 35,061.

[23] The 2014–15 renovation and expansion was designed by the New York-based firm, Architecture Research Office in close collaboration with Heery International.

[28] On June 9, 2019, the United States men's soccer team hosted Venezuela in a friendly to prepare for the 2019 CONCACAF Gold Cup.

On November 2, 2008, Democratic presidential candidate Barack Obama held a rally at Nippert two days before the election to an estimated 27,000 attendees.

The team broke the United Soccer League regular-season record for attendance five times, drawing 30,417 fans to its game against New York Red Bulls II on September 16, 2017.

On September 29, 2018, they once again broke the USL attendance record, drawing 31,478 fans against Indy Eleven in FCC's final regular-season home game before the team's move to MLS.