It primarily serves as the home venue of the Ohio State Buckeyes football team and is also the site for the university's Spring Commencement ceremonies each May.

Beginning in 2000, the stadium was renovated and expanded in several phases, removing the track and adding additional seating, which raised the capacity to 101,568 by 2001 and to 102,329 in 2007.

[3] As early as 1913, Ohio Field at High Street and Woodruff Avenue was unable to contain the crowds attracted to many Buckeye home football games.

A public-subscription Stadium Campaign to fund the project began in October 1920 and raised over $1.1 million in pledges by January 1921, of which $975,001 were actually honored.

At the base is a slurry wall to keep out the waters from the Olentangy River; the stadium rests on the flood plain.

The rotunda at the north end of the stadium, which is now adorned with stained glass murals of the offensive and defensive squads that comprise the Buckeye football team,[5] was designed to look like the dome at the Pantheon in Rome.

This concern was put to rest at the stadium's formal dedication against Michigan on October 21, which the Wolverines won, 19–0.

In 1923, a cinder track was built around the football field, which would later be named after Olympian and Ohio State athlete Jesse Owens.

The south end zone scoreboard was also replaced by a 90-by-30-foot (27.4 m × 9.1 m) video board that is able to show replays, highlights, animations, graphics and statistical information.

In 1998, the track was removed and a 45-foot (14 m) slurry wall was built underneath the field to allow it to be lowered 14.5 feet (4.4 m), which places it below the water table.

[4] In 1971, the natural grass field was removed, and AstroTurf was installed, compliments of a donation by Lou Fisher in dedication to fellow football player Joseph Campanella.

That grass never took root because of bad weather, and the university was forced to re-sod the field again only three weeks after the old sod was laid.

The renovations also included permanent lights added to the northeast and southeast corners of the stadium, as well as atop the press box, and the playing surface was replaced.

The naming rights deal was announced August 26, 2022, and allows the company’s logos to be displayed on the field.

Ohio State's first night game in the stadium was played on September 14, 1985, when the #9 Buckeyes defeated the Pittsburgh Panthers, 10–7.

Ohio State played a total of 12 more night games before permanent lighting was installed, nine of which were against ranked opponents.

Ohio State's most recent night game was a 42–17 win versus Tennessee on December 21, 2024 as part of the 2024–25 College Football Playoff.

On May 5, 2024, a woman fell to her death from the stands atop the stadium during Ohio State's commencement ceremony.

[20] Despite the facility's size, problems like field dimensions and the lack of lighting pushed the Crew to find a new home.

[22] The stadium hosted the Ohio High School Athletic Association football championship games for all seven divisions from 2014 to 2016.

The 2016 International Champions Cup match between Real Madrid and Paris Saint-Germain was held at Ohio Stadium on July 27, 2016.

The match, won by Paris Saint-Germain 3–1, drew 86,641 fans, the largest crowd to ever see a soccer game in the state of Ohio.

The stadium had a temporary grass pitch installed over the normal turf surface for the match, which was criticized by Manchester City manager Pep Guardiola.