A Republican, he represented the 6th district in the Ohio State Senate from 2021 to 2024, covering the northern, eastern, and southern of Montgomery County.
A few hours later he announced his candidacy for Ohio State Treasurer citing an easier path to victory and his Indian heritage as credentials.
In 2024, Antani ran for Congress to fill Ohio's 2nd congressional district after Brad Wenstrup announced he would not seek re-election.
On March 14, 2018, Antani made headlines by appearing to suggest that students who were over the age of 18 should be allowed to bring rifles to school in their cars.
[14] Outside of the Ohio Senate, Antani is a member of the National Rifle Association of America and Dayton Right to Life.
[15] Beginning in 2018, Antani started serving on the national board of the Republican State Leadership Committee's Future Majority Project.
[16] Antani has received the Legislator of the Year Award by the AMVETS Department of Ohio for his work on veterans issues.