[2] Khuro received his primary education from Pilot Secondary School in Larkana, completed his Intermediate studies at D. J. Sindh Government Science College in Karachi, and graduated from Karachi university.

[citation needed] His daughter, Nida Khuhro, is a member of the Provincial Assembly of Sindh.

[3] Khuhro is the Provincial President of Pakistan Peoples Party's Sindh chapter since October 2016.

[4] He also served as the Advisor of Chief Minister of Sindh on Works and Services and also on Universities and Boards with the status of a Provincial Minister from August 2019 to August 2021 holding additional charge of the Pro-Chancellor of all public universities in Sindh.

[8][12] Nisar remained a Member of the Provincial Assembly of Sindh continuously from 1988 till 2018 representing Larkana.