The Nishnabotna Ferry House is an historic building located in Lewis, Iowa, United States.

The 1½ story, frame, Greek Revival structure was the home of Samuel Harlow Tefft who operated the cable ferry across the East Nishnabotna River from 1857 to 1859.

The road that the ferry served was originally an Indian trail that became a primary route used by western bound emigrants, a stage coach and mail route, the Underground Railroad, a later Mormon Trail, and the Mormon handcart companies.

Tefft bought the property in 1857 in order to operate the ferry, and it is assumed that the house had already been built by that time.

Tefft and his wife remained in the community and are buried in Oakwood Cemetery at Lewis.